检索范围:
排序: 展示方式:
Barriers to advancing nanotechnology to better improve and translate nanomedicines
Yuwei WANG,David W. Grainger
《化学科学与工程前沿(英文)》 2014年 第8卷 第3期 页码 265-275 doi: 10.1007/s11705-014-1442-x
关键词: nanotechnology nanomedicine drug delivery therapeutic target delivery
Probes and nano-delivery systems targeting NAD(P)H:quinone oxidoreductase 1: a mini-review
《化学科学与工程前沿(英文)》 2023年 第17卷 第2期 页码 123-138 doi: 10.1007/s11705-022-2194-7
关键词: NAD(P)H:quinone oxidoreductase 1 cancer therapy target probe nanosystem
载有穿心莲内酯的微乳液和纳米乳液制剂——改善“苦味之王” 的生物利用度、靶组织分布及功效 Review
Marta Casamonti, Laura Risaliti, Giulia Vanti, Veri Piazzini, Maria Camilla Bergonzi, Anna Rita Bilia
《工程(英文)》 2019年 第5卷 第1期 页码 69-75 doi: 10.1016/j.eng.2018.12.004
穿心莲内酯(AG)为爵床科植物穿心莲(Andrographis paniculata)的特征性成分。该植物为亚洲著名药用植物,在印度、中国和泰国得到广泛使用。《中华人民共和国药典》(简称《中国药典》)收载了中药穿心莲的药材标准,记载这种草药的煎剂可“清热、解毒、消肿”。穿心莲具有众多潜在活性,从抗炎到抗糖尿病作用,从神经保护到抗肿瘤活性,从保肝到抗肥胖特性。然而,AG的生物利用度较低、水溶性较差,因此限制了给药后在体内的分布和积累。此外,AG在胃肠道碱性和酸性环境中不稳定,据报道其半衰期极为短暂。在为提高AG的水溶性和渗透性而采取的各种策略中,技术途径是开发适合的给药系统最有用的方法。本文综述了与载有AG的微粒(MP)和纳米颗粒(NP)相关的已有研究工作。目前已开发出基于聚乳酸- 羟基乙酸(PLGA)、海藻酸和葡聚糖衍生物的微粒,分别用于肠胃外口服和肺部给药。NP包括囊泡(脂质体和类脂质体)、聚合NP(基于聚乙烯醇、聚合苯基硼酸、PLGA、人血清白蛋白、聚氰基丙烯酸乙酯和聚合物胶束)、固体脂质NP、微乳液(ME)和纳米乳液(NE)、黄金NP、纳米晶体和纳米混悬液。据报道,所述载有AG的给药系统的生物利用度、靶组织分布和功效都得到了优化。
Genome editing for the treatment of tumorigenic viral infections and virus-related carcinomas
Lan Yu, Xun Tian, Chun Gao, Ping Wu, Liming Wang, Bei Feng, Xiaomin Li, Hui Wang, Ding Ma, Zheng Hu
《医学前沿(英文)》 2018年 第12卷 第5期 页码 497-508 doi: 10.1007/s11684-017-0572-1
Viral infections cause at least 10%–15% of all human carcinomas. Over the last century, the elucidation of viral oncogenic roles in many cancer types has provided fundamental knowledge on carcinogenetic mechanisms and established a basis for the early intervention of virus-related cancers. Meanwhile, rapidly evolving genome-editing techniques targeting viral DNA/RNA have emerged as novel therapeutic strategies for treating virus-related carcinogenesis and have begun showing promising results. This review discusses the recent advances of genome-editing tools for treating tumorigenic viruses and their corresponding cancers, the challenges that must be overcome before clinically applying such genome-editing technologies, and more importantly, the potential solutions to these challenges.
关键词: genome-editing tools tumorigenic virus delivery method off-target effect virus-related carcinoma
Biodegradable polymethacrylic acid grafted psyllium for controlled drug delivery systems
Ranvijay KUMAR, Kaushlendra SHARMA
《化学科学与工程前沿(英文)》 2013年 第7卷 第1期 页码 116-122 doi: 10.1007/s11705-013-1310-0
关键词: psyllium acetyl salicylic acid in-vitro drug release swelling biodegradation
Engineering platelet-mimicking drug delivery vehicles
Quanyin Hu, Hunter N. Bomba, Zhen Gu
《化学科学与工程前沿(英文)》 2017年 第11卷 第4期 页码 624-632 doi: 10.1007/s11705-017-1614-6
关键词: drug delivery platelets nanomedicine bio-inspired biomimetic
Nan Zheng, Ziyuan Song, Yang Liu, Lichen Yin, Jianjun Cheng
《化学科学与工程前沿(英文)》 2017年 第11卷 第4期 页码 521-528 doi: 10.1007/s11705-017-1612-8
关键词: α-helical polypeptide plant gene delivery protoplast intact leaves transfection
Zhijian CHEN, Wei LI,
《化学科学与工程前沿(英文)》 2010年 第4卷 第1期 页码 1-1 doi: 10.1007/s11705-009-0306-2
Controlled drug delivery systems: the next 30 years
Yeonhee YUN,Byung Kook LEE,Kinam PARK
《化学科学与工程前沿(英文)》 2014年 第8卷 第3期 页码 276-279 doi: 10.1007/s11705-014-1426-x
关键词: drug delivery history formulation barriers nanotechnology clinical product
Bioorthogonal chemistry based on-demand drug delivery system in cancer therapy
《化学科学与工程前沿(英文)》 2023年 第17卷 第4期 页码 483-489 doi: 10.1007/s11705-022-2227-2
关键词: bioorthogonal reaction cancer therapy metabolic glycoengineering bioorthogonal catalytic patch
Effect of the new maternity insurance scheme on medical expenditures for caesarean delivery in Wuxi,
null
《医学前沿(英文)》 2016年 第10卷 第4期 页码 473-480 doi: 10.1007/s11684-016-0479-
Aiming to control rising medical expenditures and help improve China’s healthcare systems, this study examined whether a cap-based medical insurance scheme with shared financial interest between the insurance and healthcare providers is effective in containing hospitals’ C-section medical expenditures. We used 6547 caesarean delivery case records from a teaching tertiary-level general public hospital located in Wuxi, China (2004–2013), and used the Chow test to investigate the possibility of significant variation in mean medical expenditures for caesarean deliveries pre- and post-reform. We also used paired sample t-tests and linear regression models to compare the mean medical expenditures between insured and uninsured women undergoing caesarean delivery during the post-reform period. After the scheme’s implementation, medical expenditures for caesarean deliveries declined and the medical expenditures of women covered by the scheme were significantly lower than those of uninsured patients. These findings indicated the scheme’s effectiveness in minimizing caesarean delivery expenditures. The cap-based medical insurance scheme with shared financial interest between insurance and healthcare providers would likely steer healthcare providers’ behaviors in a more cost-effective direction.
关键词: maternity insurance scheme financial incentive caesarean delivery medical expenditure China
Economic analysis of a hybrid solar-fuel cell power delivery system using tuned genetic algorithm
Trina SOM, Niladri CHAKRABORTY
《能源前沿(英文)》 2012年 第6卷 第1期 页码 12-20 doi: 10.1007/s11708-012-0172-3
关键词: distributed energy resources (DERs) microgrid tuned genetic algorithm (TGA)
Zeolitic imidazolate framework-8 (ZIF-8) for drug delivery: A critical review
Simin Feng, Xiaoli Zhang, Dunyun Shi, Zheng Wang
《化学科学与工程前沿(英文)》 2021年 第15卷 第2期 页码 221-237 doi: 10.1007/s11705-020-1927-8
关键词: zeolitic imidazolate framework-8 (ZIF-8) synthesis methods applications drug delivery
Wen-Can Huang,Wenjie Wang,Wei Wang,Yanan Hao,Changhu Xue,Xiangzhao Mao,
《工程(英文)》 doi: 10.1016/j.eng.2023.05.024
关键词: Polysaccharides Chitosan Hydrogels Oral delivery Intestine-targeted
Molecular engineering of dendrimer nanovectors for siRNA delivery and gene silencing
Yu Cao, Xiaoxuan Liu, Ling Peng
《化学科学与工程前沿(英文)》 2017年 第11卷 第4期 页码 663-675 doi: 10.1007/s11705-017-1623-5
关键词: gene therapy RNAi therapeutics dendrimer nanovectors gene silencing
标题 作者 时间 类型 操作
Barriers to advancing nanotechnology to better improve and translate nanomedicines
Yuwei WANG,David W. Grainger
期刊论文
载有穿心莲内酯的微乳液和纳米乳液制剂——改善“苦味之王” 的生物利用度、靶组织分布及功效
Marta Casamonti, Laura Risaliti, Giulia Vanti, Veri Piazzini, Maria Camilla Bergonzi, Anna Rita Bilia
期刊论文
Genome editing for the treatment of tumorigenic viral infections and virus-related carcinomas
Lan Yu, Xun Tian, Chun Gao, Ping Wu, Liming Wang, Bei Feng, Xiaomin Li, Hui Wang, Ding Ma, Zheng Hu
期刊论文
Biodegradable polymethacrylic acid grafted psyllium for controlled drug delivery systems
Ranvijay KUMAR, Kaushlendra SHARMA
期刊论文
Introduction to the special issue of the 2009 International Symposium on Crystal Engineering & Drug Delivery
Zhijian CHEN, Wei LI,
期刊论文
Effect of the new maternity insurance scheme on medical expenditures for caesarean delivery in Wuxi,
null
期刊论文
Economic analysis of a hybrid solar-fuel cell power delivery system using tuned genetic algorithm
Trina SOM, Niladri CHAKRABORTY
期刊论文
Zeolitic imidazolate framework-8 (ZIF-8) for drug delivery: A critical review
Simin Feng, Xiaoli Zhang, Dunyun Shi, Zheng Wang
期刊论文
A Double-Layer Polysaccharide Hydrogel (DPH) for the Enhanced Intestine-Targeted Oral Delivery of Probiotics
Wen-Can Huang,Wenjie Wang,Wei Wang,Yanan Hao,Changhu Xue,Xiangzhao Mao,
期刊论文